RISK OF DEVELOPMENT CARDIOVASCULAR СOMPLICATIONS IN PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC SYNDROME

The combination of arterial hypertension and metabolic syndrome leads to an increased risk development cardiovascular complications. Early detection asymptomatic target organ damage determine additional is important, because pressure-dependent subclinical several organs reflects progression along the disease continuum. SCORE scale based on data from a number recent European multicenter studies takes into account all variants fatal events over 10-year period. However, does not take presence such factors for complications as insulin resistance, endothelial dysfunction, microalbuminuria
 aim was assess ten-years in hypertensive's with syndrome, depending type insulinemia, microalbuminuria.
 Materials methods. Were examined 96 patients (34 men, 62 women) average age (57±9) years. Office blood pressure measurement, level total cholesterol microalbuminuria daily urine were determined patients. An oral glucose tolerance test performed parallel determination endogenous insulin, endothelin-1, vasculoendothelial growth factor serum by immunoenzymatic method. Patients divided three groups. Group 1 included 29 normal basal postprandial levels insulin; 2nd group – 39 reactive hyperinsulinemia, 3rd 28 spontaneous hyperinsulinemia. To estimate risk, version countries high mortality used. Moderate criteria are defined index 1-4%, 5-9% very ≥ 10%.
 Research results. A moderate prevailed almost 52% 35% 2 48% 43% 3 highest systolic diastolic characteristic high-risk hyperinsulinemia combined impaired tolerance, increasing 1.7 times under obesity, endothelin 7 times, 2.7 75% cases.
 Conclusions. More than half hypertensive have according scale, which associated hypercholesterolemia disorders vasoregulation. signs increases severity resistance creates prerequisites atherosclerosis.